Dear Colleagues,
The Gates Foundation and LifeArc* have launched a joint Grand Challenges request for proposals, "Innovations for Exceptionally Low-Cost Monoclonal Antibody (mAb) Manufacturing".
Monoclonal antibodies are one of the most powerful tools in modern medicine. They are highly specific, safe, and effective medicines for a range of conditions, including treating non-communicable diseases and preventing and treating infectious diseases. These biologic therapies already save lives and improve the quality of life for many millions of patients, but high production costs continue to limit access to mAbs, especially for patients in low- and middle-income settings. While there are indication-specific dosage requirements for mAbs, it is broadly understood that to close the equity gap in mAb global access, we need to reach a target cost of $10 per gram of purified, released mAb, a goal long championed by our late colleague, Dr. Steve Hadley, former Senior Program Officer at the Gates Foundation.
This Grand Challenge is calling for proposals that offer radical, innovative, and technically feasible pathways to achieving the $10/gram target. We invite you to bring your expertise, creativity, and passion to this effort and help shape a future where the best medical treatments are available to everyone, everywhere.
The Gates Foundation and LifeArc are collaborating on this request for proposals to support a range of different approaches and build a critical mass of scientific innovation focused on reaching the target. While the organizations will employ a coordinated review process, individual grants will be funded either by the Gates Foundation or by LifeArc.
Applications for proof-of-concept projects (Option A) are due by 11:30 AM PST, January 31st, 2025.
Additionally, the Gates Foundation is interested in proposals from organizations that have already completed proof-of-concept work with feasible pathways to achieving the $10/gram and are interested in additional support (Option B). Applicants may apply with solutions meeting the criteria for either Option A or Option B, but not both.
Applications for Option B are due by 11:30 AM. PST, May 31st, 2025.
Please review the full details for both opportunities on our Grand Challenges website. We are eager to receive as many proposals as possible. Please forward this email to colleagues who may be interested in applying. If you were forwarded this message, please sign up on the Grand Challenges website to receive emails announcing grant opportunities.
Sincerely,
The Global Partnerships & Grand Challenges team
*LifeArc is a charity registered with the Charity Commission for England and Wales under registration number 1015243 and a charity registered in Scotland with the Office of the Scottish Charity Regulator under registration number SC037861. LifeArc is also a company limited by guarantee, with company 2698321, incorporated under the laws of England and Wales at 7th Floor, Lynton House 7-12 Tavistock Square, London WC1H 9LT.
(C) 1999-2024 Bill & Melinda Gates foundation.