This conference is the third in a series of EMBO meetings and represents the continuation of the signal transduction Dubrovnik meetings which started in 1998 and is held every two years in the same venue, the beautiful Hotel Croatia in Cavtat, close to the town of Dubrovnik. In 2018 we will celebrate the 20th anniversary of this meeting, which has meanwhile grown into one of the most prestigious conferences on signal transduction with up to 300 participants from all over the world.

The focus of the 2018 meeting will be on the challenges that cancer evolution and the complex tumor-stroma interactions pose to modern cancer treatments. The program contains the following main subjects: Signalling mechanisms in cancer, genomic integrity and cancer, cancer stem cells, tumor-stroma interactions, cancer evolution and tumor heterogeneity, cancer therapy.

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