Redox homeostasis is a prerequisite for human health, in which the physiological levels of nonradical reactive oxygen species function as the primary second messengers to modulate physiological redox signaling by orchestrating multiple redox sensors. However, redox dysregulation leads to biomolecule damage and subsequent occurrence of various diseases such as cardiovascular pathology, cancer and neurodegeneration.

This FEBS Advanced Lecture Course aims to tackle the intricate redox signaling network that has evolved around cellular metabolism, generation of radical species, and cellular responses that affect growth and death. The speakers will discuss different aspects of redox signaling involved in both physiological and pathological conditions and how dysfunction of this complex signaling network can be targeted to prevent/slow disease onset and progression. Further, different model systems as well as methodological approaches, including transcriptomics, metabolomics, and proteomics, will be discussed to provide students a wider perspective of questions, models, and approaches that can be developed for future studies.

The program offers a diverse array of activities, including training lectures, poster sessions, short presentations by all participants, and “meet the expert” sessions that provide young scientists with the opportunity to engage directly with leading international experts in redox biology.

The course will target early-career researchers (ECRs) from different areas of basic biological sciences and medicine, primarily experienced PhD students and post-doctoral level scientists within 5 years after completion of their doctorate. ECRs will be selected primarily based on their qualifications relevant to the course content, their potential to contribute to the breadth of science, and the benefit they are likely to obtain for their future careers, while ensuring a broad participation from different FEBS constituent countries and a focus on equality and diversity.

Image: neurons stained with DCF, for ROS assay; from lab of M. Perluigi.

The course website is under construction. Please monitor the Advanced Courses calendar for when the link becomes available.

Location: Spetses Island, Greece

Organizers: Marzia Perluigi, Fabio Di Domenico, Niki Chondrogianni