Standort: Vienna
Art: Vollzeit
Firma: St. Anna Children´s Cancer Research Institute (CCRI)
Eingetragen am: 2021-01-08

Tumor cell plasticity is the basis of cancer progression and metastasis. A better understanding of the underlying
molecular mechanisms may allow tailoring of effective anti-metastatic treatments. Fluctuations in driver oncogene
expression has recently been identified to promote the invasive and metastatic potential of Ewing sarcoma, a highly
aggressive bone cancer in children and adolescents.

Funded by the Austrian Science Fund FWF, we seek to explore causes and consequences of oncogene fluctuations
in Ewing sarcoma, and to identify therapeutic agents blocking EMT-like transitions and consequently progression
of this devastating disease.  

We are looking for a curious molecular biologist at post-doctoral level to explore and target mechanisms of
tumor cell plasticity by employing a broad spectrum of high-throughput genomic, functional, and cell biological

As a postdoc, you will

  • Join the Molecular Biology of Solid Tumors group at CCRI, led by Heinrich Kovar
  • Plan and perform genetic perturbation experiments in vitro and in vivo, and analyze functional consequences using cutting-edge molecular and imaging technologies
  • Apply a broad spectrum of cell biology, molecular biology, and omics methods
  • Bring in your own ideas and expertise to make the project your own
  • Interpret, present, and discuss your results with biologists and clinical researchers locally and internationally
  • Independently monitor the literature and community resources to keep abreast with latest developments and to identify information, data, and methods to integrate in your own work
  • Write papers, visit conferences, review papers, apply for fellowships, and contribute to grants
  • Contribute to the supervision of junior group members

Your profile

  • PhD in a relevant life sciences subject (molecular biology, biotechnology, genomics, pharmacy, etc.)
  • At least one year of postdoctoral experience
  • At least two first-author publications in reputable journals
  • Good knowledge of and prior experience in cancer biology and/or developmental biology
  • Extensive experience with state-of-the-art cell culture, molecular biology, gene editing and omics technologies
  • Experience with genomic/epigenomic technologies is desirable
  • Excellent verbal and written communication skills in English (German not required)
  • An exceptional level of curiosity, enthusiasm, determination, and creativity

Our offer

  • A three-years-contract for a challenging position in a meaningful, inspiring, and international environment
  • An outstanding working atmosphere in a strong team with excellent research and development opportunities
  • Access to state-of-the-art infrastructure
  • Flexible working hours, discounted lunch in our canteen and other great benefits
  • Great location in the center of Vienna, a capital of biomedical research in Europe with excellent quality of life
  • A fair and attractive salary package according to the Austrian Science Fund FWF (


Who we are
The St. Anna Children’s Cancer Research Institute (CCRI), located in the center of Vienna, the world’s most livable
city and one of Europe’s most important places for biomedical research and life sciences, is an international and
multidisciplinary competence center striving to improve treatment of children and adolescents with cancer by
connecting translational and clinical research with open-minded exploration of basic disease mechanisms. Through
close cooperation between clinic and research, the CCRI provides an ideal environment for cutting-edge research
and its translation into clinical practice. To achieve our ultimate goal of advancing the well-being of patients, the
CCRI constantly pushes scientific boundaries and strongly promotes close collaboration and exchange with external
institutions like the Medical University of Vienna, the Technical University and the University of Natural Resources
and Life Sciences, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, the Institute
of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) and the Institute of Molecular Pathology

The Molecular Biology of Solid Tumors Group at CCRI performs predominantly basic research with the aim of
translating clinical observations into molecular patterns, and molecular patterns into diagnostic/prognostic tools
and novel treatment options. Since many years, we have been focusing on understanding the molecular etiology
of pediatric bone sarcomas. There is an urgent need for new treatment options for these very malignant cancers
in children and adolescents. The ultimate goal of our research is the development of novel disease models that
allow for preclinical testing and optimization of innovative therapies.

The CCRI is an equal opportunity employer. We value diversity and are committed to providing a work environment
of mutual respect to everyone without regard to race, color, religion, national origin, age, gender identity or
expression, disability, or any other characteristic protected by applicable laws, regulations and ordinances.

Find more information here: or

Your application

Please send your application via email to Prof. Heinrich Kovar, Applications should at least
contain your Curriculum Vitae, a motivation letter, list of publications (please mark / explain your three top
contributions), and the contact details of three references. Applications will be reviewed on a rolling basis. The
position shall remain open until a suitable candidate is found. The start date for the position is in spring 2021.

Anhang: hier