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CATEGORIES:Kongress
SUMMARY:Protein termini 2026: From mechanisms to biological impact
LOCATION:Palermo, Italy
DESCRIPTION;ENCODING=QUOTED-PRINTABLE:	\n\n		The FEBS Workshop 'Protein termini 2026: From mechanisms to biol
 ogical impact' will be the 5th biennial conference of the International
  Society for Protein Termini (ISPT) and appear within the FEBS Advanced Cou
 rses programme. We will explore the fundamental roles of protein termini ac
 ross kingdoms of life, with emphasis on how terminal modifications regulate
  protein fate, signaling, and disease.\n	\n\n		The four-day programme is st
 ructured around eight thematic sessions that follow the functional journey 
 of protein termini — from synthesis and co-translational processing, 
 through terminal modifications, stability and signaling, to applications in
  medicine and biotechnology.\n	\n\n		More about our conference programme:\n
 	\n\n		The Palermo workshop will explore the fundamental roles of protein t
 ermini across kingdoms of life, with emphasis on how terminal modifications
  regulate protein fate, signaling, and disease. Highlights include two keyn
 ote lectures (Beckmann and Hartl), a dedicated session on terminal degrons 
 (ISPT Lecture), and a closing session on therapeutic innovation. This progr
 ession fosters interdisciplinary dialogue across structural biology, cell b
 iology, proteomics, synthetic biology, and translational research.\n	\n\n		
 Our workshop will explore the critical roles of protein termini in biologic
 al processes, including proteostasis. As the first part of a nascent protei
 n to emerge from the ribosome, the N-terminus undergoes co-translational mo
 difications that dictate protein fate, while ribosome-associated factors an
 d modifying enzymes act on both termini to influence folding, localization,
  and stability. The C-terminus, though historically less studied, is now re
 cognized as equally important in regulating protein interactions and degrad
 ation. Additionally, protease-mediated processing generates new N- and C-te
 rmini, adding another layer of regulation. Understanding how these processe
 s coordinate during translation and beyond remains a major question in biol
 ogy with broad biological and therapeutic implications.\n	\n\n		The worksho
 p will span a logical progression from protein synthesis to terminal modifi
 cations, their role in degradation, functions beyond degradation, and thera
 peutic applications. It will open with “Molecular Choreography: Ribos
 omal Coordination of Terminal Fate”, featuring a keynote lecture by P
 rof. Roland Beckmann (LMU Munich) on N-terminal modifications during nascen
 t chain synthesis, followed by talks on structural and mechanistic advances
  of ribosome-associated enzymatic factors. Next, the sessions “Termin
 al Modifications I & II: Mechanisms & Functions” will explore
  the full spectrum of terminal modifications, from well-established ones li
 ke N-terminal acetylation to recently discovered modifications such as Nt-m
 ethylation. The next two sessions, ”N-Terminal Signals in Protein Sta
 bility and N-Degrons and Their N-recognins”, will explore the role of
  N-terminal modifications in regulating protein stability. These sessions w
 ill provide key insights into N-degron pathways and ubiquitin ligase functi
 on. The session “Beyond Degradation: Functional Roles of Protein Term
 ini” will highlight their broader regulatory functions. This will be 
 followed by the second keynote lecture, delivered by Prof. F. Ulrich Hartl 
 (MPI Biochemistry, Martinsried), on co-translational folding and its interp
 lay with protein termini. The workshop will conclude with two sessions &ldq
 uo;Translating Terminal Modifications: From Basic Science to Therapeutics&r
 dquo;, showcasing how advances in terminal modifications can be leveraged f
 or technological innovation and translational research where we will also i
 ndustry participation.\n\n\n	 \n
CONTACT:www.conferencecentral.org/webpage/view/45
DTSTAMP:20260608T235028Z
DTSTART;TZID=Europe/Vienna:20260603T100000
DTEND;TZID=Europe/Vienna:20260606T170000
SEQUENCE:1
TRANSP:OPAQUE
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