The ability of cell s to perceive and correctly respond to their environment is the basis of de velopment, tissue repair, and immunity as well as normal tissue homeostasis . Errors in the interplay, dynamics or localization of the involved molecul es are responsible for many diseases such as cancer, autoimmunity and diabe tes. By increasing the understanding of the complex interplay between these various components and their dynamics over time the related diseases can b e treated more effectively. Because of the recent technological revolution in advanced light microscopy (i.e. functional imaging of molecules, develop ment of caged compounds and biosensors) it is now possible to directly moni tor the dynamics of these (single) molecules and numerous biosensors in liv ing cells. Microscopic techniques like Super-resolution Microscopy, F LIM-FRET, FRAP and FCS allow us to visualize cellular signaling complexes a nd their dynamics in time and will be the topic of this FEBS practical cour se.
This 6-day advanced microscopy course for up to 20 exp erienced graduate students, postdocs and scientists will integrate theoreti cal lectures with hands-on experiments and practical experience. National a nd international experts in the field of microscopy will give an overview o f “state-of-the-art” imaging techniques and applications in bio logical research.
The course website is under construc tion. Please monitor the Advanced Courses calendar for when the link becomes available.< /em>
Location: Amsterdam, the Netherla nds
Organizers: Mark Hink