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BEGIN:VEVENT
UID:
CATEGORIES:ÖGMBT-Seminar OST
SUMMARY:Metabolic engineering strategies for lactic acid production from cellulosic biomass through consolidated bioprocessing
LOCATION:SER 12 (MUG III)
DESCRIPTION;ENCODING=QUOTED-PRINTABLE:	Announcement of a seminar with \n	 \n	Roberto Mazzoli\n	 \n	5. M
 arch 2019 – 12:30 – SER 12 (MUG III)\n\n\n	 \n	Metabolic e
 ngineering strategies for lactic acid production from cellulosic biomass th
 rough consolidated bioprocessing\n	 \n	Proteomics and Metabolic Engine
 ering of Prokaryotes (PMEP), Dept. of Life Sciences and Systems Biology, Un
 iversity of Torino, Italy\n	Thayer School of Engineering, Dartmouth College
 , Hanover, New Hampshire, USA.\n	 \n\n\n	Lactic acid (LA) is among the
  most requested chemicals because of its several applications in food (e.g.
  acidifier and flavour-enhancing agent), cosmetic (emulsifying and moisturi
 ng agent) and pharmaceutical (intermediate) industries and as building bloc
 k for the synthesis of biodegradable plastic polymers (e.g. polylactides, P
 LAs). Most LA is produced through fermentation of dedicated crops (mainly c
 orn). As the global demand for LA is rapidly increasing (16.2 % annual grow
 th) such a process represents a threat for these food crops. Development of
  alternative fermentation processes based on 2nd generation (i.e. lignocell
 ulosic) feedstocks appears therefore as a priority.\n\n\n	Lignocellulose ha
 s ideal characteristics for application as feedstock in biorefinery since i
 t’s very abundant, cheap and renewable. However, lignocellulose is ve
 ry recalcitrant to biodegradation and its bioconversion currently requires 
 expensive multi-step processes which cannot compete with traditional techno
 logies. Metabolic engineering can be used to develop microbial strains able
  to catalyze single-pot fermentation, i.e. consolidated bioprocessing, of p
 lant biomass to industrially relevant products thus enabling cost-sustainab
 le 2nd generation biorefinery. Different approaches allowing construction o
 f recombinant microorganisms for direct convertion of lignocellulose to LA 
 will be illustrated highlighting the state-of the-art of these studies and 
 their main challenges. The focus will mainly concern the construction of re
 combinant cellulolytic lactic acid bacteria, and the improvement of LA prod
 uction in Clostridium thermocellum, i.e. a native cellulolytic bacterium.\n
 \n\n	 \n\n\n	Roberto Mazzoli has completed his PhD in 2003 and, since 
 2011, has been assistant professor in biochemistry at the Department of Lif
 e Sciences and Systems Biology, University of Turin (Italy). Since 1998, he
  has been studying the metabolism of bacteria aimed at industrial processes
 , e.g. bioremediation of aromatic hydrocarbons, food fermentation and produ
 ction of nutraceuticals, and biomass biorefinery. Since 2006, his main rese
 arch activity has concerned metabolic engineering of bacteria for cellulosi
 c consolidated biorefinery. He is the PI of the group of Proteomics and Met
 abolic Engineering of Prokaryotes at the Department of Life Sciences and Sy
 stems Biology, University of Turin (Italy). He has published 32 papers in p
 eer-reviewed international journals, 1 book chapter and 2 international pat
 ents.\n
CONTACT:Seminar Boku Biotechnology
DTSTAMP:20260502T124418Z
DTSTART;TZID=Europe/Vienna:20190305T123000
DTEND;TZID=Europe/Vienna:20190305T123000
SEQUENCE:1
TRANSP:OPAQUE
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