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BEGIN:VEVENT
UID:
CATEGORIES:ÖGMBT-Seminar OST
SUMMARY:Metabolic engineering strategies for lactic acid production from cellulosic biomass through consolidated bioprocessing
LOCATION:SER 12 (MUG III)
DESCRIPTION;ENCODING=QUOTED-PRINTABLE:<p align="center">	<strong>Announcement of a seminar with </strong></p><p a
 lign="center">	&nbsp;</p><p align="center">	<strong>Roberto Mazzoli</strong
 ></p><p align="center">	&nbsp;<br />	<strong>5. March 2019 &ndash; 12:30 &n
 dash; SER 12 (MUG III)</strong></p><p>	&nbsp;</p><p align="center">	<strong
 >Metabolic engineering strategies for lactic acid production from cellulosi
 c biomass through consolidated bioprocessing</strong></p><p align="center">
 	&nbsp;</p><p align="center">	Proteomics and Metabolic Engineering of Proka
 ryotes (PMEP), Dept. of Life Sciences and Systems Biology, University of To
 rino, Italy</p><p align="center">	Thayer School of Engineering, Dartmouth C
 ollege, Hanover, New Hampshire, USA.</p><p align="center">	&nbsp;</p><p>	La
 ctic acid (LA) is among the most requested chemicals because of its several
  applications in food (e.g. acidifier and flavour-enhancing agent), cosmeti
 c (emulsifying and moisturing agent) and pharmaceutical (intermediate) indu
 stries and as building block for the synthesis of biodegradable plastic pol
 ymers (e.g. polylactides, PLAs). Most LA is produced through fermentation o
 f dedicated crops (mainly corn). As the global demand for LA is rapidly inc
 reasing (16.2 % annual growth) such a process represents a threat for these
  food crops. Development of alternative fermentation processes based on 2nd
  generation (i.e. lignocellulosic) feedstocks appears therefore as a priori
 ty.</p><p>	Lignocellulose has ideal characteristics for application as feed
 stock in biorefinery since it&rsquo;s very abundant, cheap and renewable. H
 owever, lignocellulose is very recalcitrant to biodegradation and its bioco
 nversion currently requires expensive multi-step processes which cannot com
 pete with traditional technologies. Metabolic engineering can be used to de
 velop microbial strains able to catalyze single-pot fermentation, i.e. cons
 olidated bioprocessing, of plant biomass to industrially relevant products 
 thus enabling cost-sustainable 2nd generation biorefinery. Different approa
 ches allowing construction of recombinant microorganisms for direct convert
 ion of lignocellulose to LA will be illustrated highlighting the state-of t
 he-art of these studies and their main challenges. The focus will mainly co
 ncern the construction of recombinant cellulolytic lactic acid bacteria, an
 d the improvement of LA production in Clostridium thermocellum, i.e. a nati
 ve cellulolytic bacterium.</p><p>	&nbsp;</p><p>	Roberto Mazzoli has complet
 ed his PhD in 2003 and, since 2011, has been assistant professor in biochem
 istry at the Department of Life Sciences and Systems Biology, University of
  Turin (Italy). Since 1998, he has been studying the metabolism of bacteria
  aimed at industrial processes, e.g. bioremediation of aromatic hydrocarbon
 s, food fermentation and production of nutraceuticals, and biomass biorefin
 ery. Since 2006, his main research activity has concerned metabolic enginee
 ring of bacteria for cellulosic consolidated biorefinery. He is the PI of t
 he group of Proteomics and Metabolic Engineering of Prokaryotes at the Depa
 rtment of Life Sciences and Systems Biology, University of Turin (Italy). H
 e has published 32 papers in peer-reviewed international journals, 1 book c
 hapter and 2 international patents.</p>
CONTACT:Seminar Boku Biotechnology
DTSTAMP:20260429T091908Z
DTSTART;TZID=Europe/Vienna:20190305T123000
DTEND;TZID=Europe/Vienna:20190305T123000
SEQUENCE:1
TRANSP:OPAQUE
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