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Veranstaltung SUMMARY:AlgoSB 2019: Mathematical and Computational Methods for Structured RiboNucleic Acids LOCATION:Marseille, France DESCRIPTION;ENCODING=QUOTED-PRINTABLE:\n\n AlgoSB 2019: Mathematical and Computational Methods for Structured Rib oNucleic Acids International Winter School in Algorithms in Structural Bioi nformatics 14-18 JANUARY 2019 Centre International de Rencontres Math&eacu te;matiques (CIRM), Marseille, France https://algosb2019.sciencesconf.org/ *Registration deadline extended: 29 Oct 2018* _____________________________ _______________________________ We are pleased to announce the 6th edition of the Algorithms in Structural Bioinformatics (AlgoSB) winter school. The aim of AlgoSB is to introduce advanced methods in Structural Bioinformatic s in the largest sense, giving special attention to interdisciplinary appro aches. This year focus will be on computational methods for RNA structure m odelling. The school will take place at Centre International de Rencontres Mathématiques (CIRM), Marseille, France, located in Luminy in the be autiful Calanques, from January 14 to 18, 2019. Topics covered (in theory and practice): * RNA 2D folding * RNA folding kinetics * RNA design * Compa rative folding * 3D modeling and docking Lectures are structured to provid e a brief introduction to the topic of the day and then proceed to advanced concepts  and methods, in connection with real-life applications. PR OGRAM OVERVIEW Each day consists of morning lectures by experts in the fiel d, followed by a practical session on participants laptops in the afternoon . The topics of the classes include: I   RNA 2D folding: Introdu ction and advanced thermodynamics-based predictions Ronny Lorenz - TBI, Uni versity of Vienna, Austria Ivo Hofacker - TBI, University of Vienna, Austri a Main topics: Free-energy minimization; Partition-function based methods; Statistical sampling; Enzymatic/chemical probing-guided predictions; pseudo knots; basic 2D RNA-RNA interactions. II   RNA folding kinetics and energy landscapes Ronny Lorenz - TBI, University of Vienna, Austria Jua n Cortés - LAAS-CNRS, Toulouse, France Frédéric Cazals - INRIA, Sophia-Antipolis, France Charles Robert - LBT, IBPC, Paris, Franc e Main topics: Theoretical foundations of kinetic analysis; Advanced sampli ng of approximated energy landscapes; Basin hopping graphs; Energy Barrier estimation/Transition rates; Master equation resolution; Co-transcriptional folding; Comparison of energy landscapes. III  RNA design in theory and practice Sven Findeiss - University of Leipzig, Germany Main topics: In verse folding; Ensemble defect optimization; Sequence constraints; mRNA des ign; Programmatically-switching molecules; Design of RNA sensors. IV Compa rative methods for structure analysis Sebastian Will - TBI, University of V ienna, Austria Main topics: Information-based methods; Simultaneous alignme nt/folding of homologs; Covariance models; Genome-wide screens; Comparative modeling; Structural indexing and clustering methods; Comparative RNA-RNA interactions. V  RNA-protein interactions and coarse-grained molecula r dynamics for RNA Isaure Chauvot de Beauchêne - CNRS & LORIA, Un iversity of Lorraine, France Samuela Pasquali - Faculté de Pharmacie , Université Paris-Descartes, France Main topics: RNA force fields; 3D coarse-grained molecular dynamics; Atomistic simulation; Prediction/anno tation of non-canonical modules; Gradient-descent based methods; Macro-mole cular docking; RNA-protein interactions prediction; VENUE The Algorithms i n Structural Bioinformatics school will take place on the beautiful French mediterranean coastline, at the Centre International de Rencontres Math&eac ute;matiques (CIRM), Marseille, France, located in Luminy. AUDIENCE The Al goSB school is targeted towards PhD students, postdocs, and junior research ers from public research institutions and industry, both in France and inte rnationally. This school is limited to 65 participants. It is expected that all will stay for the whole duration of the school. APPLICATION To apply, visit our website (https://algosb2019.sciencesconf.org/page/signup). Pleas e provide a short motivation letter (max. 2 pages) summarizing your researc h interests and a short CV. You can enter this information directly as plai n text or provide links to pdfs. Application deadline: October 15, 2018 -&g t; October 29, 2018 Notifications: Nov 1st, 2018. REGISTRATION (opens earl y Decembre 2018) Registrations fees include housing at the CIRM, lunches an d coffee breaks: - 350 euros for academics at public research institutions and universities - 500 euros for industry Selected participants are request ed to proceed to the payment by Jan 1st 2019. Fees may be waived for deser ving applicants unable to secure funding (please notify us rather than refr aining from participating). AlgoSB 2019 organizers  Yann Ponty, LIX, CNRS & Ecole Polytechnique, Palaiseau, France  Andrea Tanzer, TBI, University of Vienna, Austria Juan Cortès, LAAS-CNRS, Toulouse, Fr ance Charles Robert, LBT-CNRS, IBPC, Paris, France Frédéric C azals, INRIA Sophia Antipolis - Mediterranee, France\n CONTACT:https://algosb2019.sciencesconf.org/ DTSTAMP:20260426T160108Z DTSTART;TZID=Europe/Vienna:20190114T090000 DTEND;TZID=Europe/Vienna:20190118T180000 SEQUENCE:1 TRANSP:OPAQUE END:VEVENT END:VCALENDAR