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Veranstaltung SUMMARY:AlgoSB 2019: Mathematical and Computational Methods for Structured RiboNucleic Acids LOCATION:Marseille, France DESCRIPTION;ENCODING=QUOTED-PRINTABLE:

AlgoSB 2019: Mathematical and Computational Methods for Structured
RiboNucleic Acids
International Winter School in Algorithms in Structu ral Bioinformatics

14-18 JANUARY 2019
Centre International de Ren contres Mathématiques (CIRM), Marseille, France
http s://algosb2019.sciencesconf.org/
*Registration deadline extended: 29 Oct 2018*
_________________________________________________ ___________

We are pleased to announce t he 6th edition of the Algorithms in
Structural Bioinformatics (AlgoSB) winter school. The aim of Alg oSB is
to introduce advan ced methods in Structural Bioinformatics in the
largest sense, giving special attention to interdisc iplinary approaches.
This year focus will be on computational methods for RNA structure
modelling.
The school will take place at Centre International de Rencontres
Mathé ;matiques (CIRM), Marseille, France, located in Luminy in the
beautiful Calanques, from January 14 t o 18, 2019.

Topics covered (in theory an d practice):
* RNA 2D fol ding
* RNA folding kineti cs
* RNA design
* Comparative folding
* 3D modeling and docking

Lectures are structured to provide a brief introduc tion to the topic of
the day and then proceed to advanced concepts  and methods, in
connection with real-life applicatio ns.

PROGRAM OVERVIEW
Each day consists of morning lectures by exp erts in the field, followed
by a practical session on participants laptops in the afternoon. The
topics of the classes includ e:

I   RNA 2D folding: Introdu ction and advanced thermodynamics-based
predictions
Ronny Lorenz - TBI, University of Vienna, Austria
Ivo Hofacker - TBI, University of Vienna, Austri a
Main topics: Free-energ y minimization; Partition-function based methods;
Statistical sampling; Enzymatic/chemical probing-g uided predictions;
pseudo knots; basic 2D RNA-RNA interactions.

II   RNA folding kinetics and energy landscapes
Ronny Lorenz - TBI, University of Vienna, Au stria
Juan Cortés - LAAS-CNRS, Toulouse, France
Frédéric Cazals - INRIA, Sophia-Antipolis, France
Charles Robert - LBT, IBPC, Par is, France
Main topics: T heoretical foundations of kinetic analysis; Advanced
sampling of approximated energy landscapes; Bas in hopping graphs; Energy
Barrier estimation/Transition rates; Master equation resolution;
Co-transcriptional folding; Compar ison of energy landscapes.

III  RNA design in theory and practice
Sven Findeiss - University of Leipzig, Germany
Main topics: Inverse folding; Ensemble defect o ptimization; Sequence
con straints; mRNA design; Programmatically-switching molecules; Design< br style="font-family: Menlo-Regular; font-size: 11px;" /> of RNA sensors.

IV Comparative methods for structure analysis
Sebastian Will - TBI, University of Vienna, Austria
Main top ics: Information-based methods; Simultaneous alignment/folding
of homologs; Covariance models; Genom e-wide screens; Comparative
modeling; Structural indexing and clustering methods; Comparative
RNA-RNA interactions.

V  RNA-protein interactions and coarse-grain ed molecular dynamics for RNA
Isaure Chauvot de Beauchêne - CNRS & LORIA, University of Lo rraine, France
Samuela Pa squali - Faculté de Pharmacie, Université Paris-Descartes, Fr ance
Main topics: RNA for ce fields; 3D coarse-grained molecular dynamics;
Atomistic simulation; Prediction/annotation of non- canonical modules;
Gradie nt-descent based methods; Macro-molecular docking; RNA-protein
interactions prediction;

VENUE
The Algorithms in Structural Bioinformatics school will take place on
the beautiful French medit erranean coastline, at the Centre
International de Rencontres Mathématiques (CIRM), Marseille , France,
located in Lumi ny.

AUDIENCE
The AlgoSB school is targeted towards PhD students, postdocs, and junior
rese archers from public research institutions and industry, both in
France and internationally. This sch ool is limited to 65 participants.
It is expected that all will stay for the whole duration of the s chool.
APPLICATION
To apply, visit our website
(https://algosb2019.sciencesconf.org/page/signup).
Please provide a short motivation letter (max. 2 pages) summa rizing your
research inte rests and a short CV. You can enter this information
directly as plain text or provide links to pdfs . Application deadline:
O ctober 15, 2018 -> October 29, 2018
Notifications: Nov 1st, 2018.

REGISTRATION (opens early Decembre 2018)
Registrations fees include housing at the CIRM, lunches and coffee breaks:
- 350 euros for academics at public research institutions and universities
- 500 euros for industry
Selected participants are requ ested to proceed to the payment by Jan 1st
2019.

Fees may be waiv ed for deserving applicants unable to secure funding
(please notify us rather than refraining from p articipating).

AlgoSB 2019 organizers
 Yann Ponty, LIX, CNRS & Ecole Polytechnique, Palaiseau, France
 Andrea Tanzer, TBI, University of Vienna, Austri a

Juan Cortès, LAAS-CNRS, Toulous e, France
Charles Robert, LBT-CNRS, IBPC, Paris, France
Frédéric Cazals, INRIA Sophia Antipolis - Mediterranee, France

CONTACT:https://algosb2019.sciencesconf.org/ DTSTAMP:20260501T200031Z DTSTART;TZID=Europe/Vienna:20190114T090000 DTEND;TZID=Europe/Vienna:20190118T180000 SEQUENCE:1 TRANSP:OPAQUE END:VEVENT END:VCALENDAR